G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA
نویسندگان
چکیده
منابع مشابه
Multimerization rules for G-quadruplexes
G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures. Although most of these 256 variants existed primarily as monomers under the conditions of our scre...
متن کاملSmall molecule regulated dynamic structural changes of human G-quadruplexes
Department of Organic Chemistry, Indian A Jadavpur, Kolkata-700032, India. E-mail: oc Department of Physical Chemistry, Indian A Jadavpur, Kolkata-700032, India Institute of Organic Chemistry and Chemica Center for Biomolecular Magnetic Resonance Frankfurt am Main, Germany † Electronic supplementary information synthetic procedures, characterization d NMR spectra, sm-FRET, shot noise, FCS NMR s...
متن کاملG-Quadruplexes: From Guanine Gels to Chemotherapeutics
G-quartets are square planar arrangements of four guanine bases, which can form extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex structures were long regarded as an in vitro phenomenon, but the widespread presence of suitable sequences in genomes and the identification of proteins that stabilize, modify or resolve these nucleic acid structures have provide...
متن کاملG-ribo: a new structural motif in ribosomal RNA.
Analysis of the available crystal structures of the ribosome and of its subunits has revealed a new RNA motif that we call G-ribo. The motif consists of two double helices positioned side-by-side and connected by an unpaired region. The juxtaposition of the two helices is kept by a complex system of tertiary interactions spread over several layers of stacked nucleotides. In the center of this a...
متن کاملStability of telomeric G-quadruplexes
In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes in vitro, surprisingly, no study has been ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2020
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkaa475